Tropical Journal of Pharmaceutical Research

Review Article | OPEN ACCESS

Effect, main targets and molecular mechanisms of glycyrrhiza-derived flavonoids on malignant tumor in comprehensive cancer treatment

Wei Hu^1,2, Wenzhe Ma¹, Bo Li^1,3, Yu Hou¹, Rongyang Dai^1,4

¹State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR 999078, China; ²Department of Interventional Radiology, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou 646000, China; ³Department of Hepatopathy, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou 646000, China; ⁴Southwest Medical University, Luzhou 646000, China.

For correspondence:- Rongyang Dai Email: dryrun2502@163.com

Accepted: 29 December 2023 Published: 30 January 2024

Citation: Hu W, Ma W, Li B, Hou Y, Dai R. Effect, main targets and molecular mechanisms of glycyrrhiza-derived flavonoids on malignant tumor in comprehensive cancer treatment. Trop J Pharm Res 2024; 23(1):223-230 doi: 10.4314/tjpr.v23i1.28

© 2024 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Glycyrrhiza flavonoids (GF) are essential antitumor components of Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata roots and tubers, with antioxidant, anti-inflammatory, antibacterial, immune-enhancing amongst other properties. In recent years, significant progress has been made in understanding the mechanisms and targets of GF in various pharmacological settings. This review summarizes the clinical value, targets and research progress of the molecular mechanisms underlying GF in the treatment of malignant tumors. This will provide as a theoretical foundation for further studies into GF as a therapeutic option in the management of cancerous tumors.

Keywords: Glycyrrhiza flavonoids, Anti-tumor, Molecular mechanism